Born in Aguascalientes, Aguascalientes, in central Mexico, Hermosillo's films often explore the hypocrisy of middle-class Mexican values.
He worked with Gabriel García Márquez on Mary My Dearest (1979) and The Summer of Miss Forbes (1988). His film Homework (1991) was entered into the 17th Moscow International Film Festival where it won a Special Mention.
At the time of his death, Hermosillo was teaching filmmaking at the University of Guadalajara and had recently collaborated with his students on several projects.
On 13 January 2020, Hermosillo died at the age of 77, 9 days before his 78th birthday.