Zacarías began directing for film in 1933. Even from his early career, he developed a reputation for recognizing new acting talent; he promoted the careers of some of Mexico's most notable actors including Pedro Armendáriz in Rosario (1935), María Félix, Marga López, Esther Fernández, Pedro Infante, Tin Tan, Cantinflas, and Manuel Medel.
His 1961 film Juana Gallo was entered into the 2nd Moscow International Film Festival. Zacarías directed his last film in 1986. His son is film director Alfredo Zacarias. His granddaughter is playwright Karen Zacarias.