He made his film directional debut in 2015 with the highest grosser of the year, Jawani Phir Nahi Ani. He is a frequent collaborator with Humayun Saeed, having directed Jawani Phir Nahi Ani, which became a huge success at the box office and is currently the third highest-grossing film. Punjab Nahi Jaungi, which is currently the second-highest-grossing film, and Jawani Phir Nahi Ani 2, which is currently the highest-grossing film.
Nadeem Baig began his career as a television director. He has directed various television serials such as Ladies Park (2011), Omer Dadi Aur Gharwale (2012), Annie Ki Ayegi Baraat (2012), and Pyarey Afzal (2013).2019's most highly rated drama which is shown by ARY Digital, (Mere Paas Tum Ho) is also on his credit as director. Baig has also co-produced Takkay Ki Ayegi Baraat and Azar Ki Ayegi Baraat.
He made his Lollywood debut with the 2015 comedy film Jawani Phir Nahi Ani which became a huge success at the box office and is currently the third highest-grossing film. ever His next film was the Romantic comedy film Punjab Nahi Jaungi which released on 1 September 2017, it became the second highest-grossing Pakistani film, collecting over Rs.51 crore at the box office.
Currently, He has directed the sequel of JPNA Jawani Phir Nahi Ani 2 which released on Eid-al-Adha 2018 and broke existing records in Pakistan. It is the highest-grossing Pakistani film.